Which drug class best prevents idiopathic ulcer bleeding recurrence?
Trial compares a PPI with an H2-receptor antagonist for Helicobacter pylori-negative ulcers
Lansoprazole and famotidine have comparable effects in preventing recurrent idiopathic gastroduodenal ulcer bleeding, a two-year randomised clinical trial shows.
Helicobacter pylori-negative idiopathic ulcers, now recognised as a distinct disease entity from H. pylori-associated ulcers, carry a much higher risk of recurrent bleeding, Hong Kong researchers note.
