‘We did not expect these results’: Testosterone therapy linked to higher fracture risk

Middle-aged and older men with hypogonadism had higher fracture incidence with hormone treatment versus placebo.

Testosterone treatment may increase fracture risk in middle-aged and older men with hypogonadism, according to new research that contradicts conventional wisdom.

While exogenous testosterone has been shown to improve bone mineral density in men with hypogonadism, US doctors say this benefit may not translate into a lower incidence of clinical fractures.