Immunological reset? CAR T-cell therapy shows promise for autoimmune diseases
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Novel blood cancer immunotherapies could induce an “immunological reset” in patients with severe and treatment-refractory autoimmune disease, German rheumatologists report.
In a case series of 15 adults — all of whom had failed multiple immune suppressive treatments — the doctors showed that chimeric antigen receptor (CAR) T-cell therapy led to drug-free remission after an average of 15 months’ follow-up.