Higher inflammation predicts mortality in colon cancer: study

Elevated inflammatory biomarkers were associated with up to double the mortality risk
Sarah Simpkins
Colon (illustration)

Increased inflammation after diagnosis of stage III colorectal cancer is linked to a 50% or higher increased risk of mortality and recurrence, US researchers report.

Results from the largest-of-its-kind study to date specifically implicate three inflammatory biomarkers — interleukin-6 (IL-6), soluble TNF-α receptor 2 (sTNF-αR2) and high-sensitivity CRP (hsCRP) — in worse survival outcomes in this setting.