Buprenorphine-naloxone combo safe for pregnant women: study

Buprenorphine-naloxone was associated with better outcomes than buprenorphine alone on some measures.

Buprenorphine combined with naloxone does not increase the risk of major congenital malformations in pregnant women with opioid use disorder, a Journal of the American Medical Association study has found. 

While buprenorphine-naloxone is commonly used for opioid use disorder, the lack of perinatal safety data has limited use in pregnant women, Harvard Medical School researchers said.