Adjuvant radiotherapy ‘reduces mortality’ in pN1 prostate cancer
Researchers have quantified the survival benefit of adjuvant radiotherapy after radical prostatectomy compared with early salvage radiotherapy
Patients with advanced prostate cancer who undergo adjuvant radiation therapy after prostatectomy have a lower risk of death than those receiving early salvage radiotherapy, a large cohort study shows.
The results support the use of adjuvant radiotherapy in this setting, German researchers say, but only in those with four or more positive pelvic lymph nodes.
They added that their findings will likely aid clinical decision-making given the lack of high-level evidence to guide the timing of radiation therapy in pN1 prostate cancer.
The team examined data from 18,000 men (median age 64) treated with radical prostatectomy and pelvic lymph node assessment at the University Medical Centre Hamburg-Eppendorf over two decades.
