Bone density loss from puberty blockers ‘reversible’ in transgender patients
Bone density loss in teenagers with gender dysphoria prescribed puberty blockers is mostly reversible with long-term gender-affirming hormone treatment in adulthood, Dutch doctors report in a landmark study.
While bone mineral accrual is suspended during puberty suppression with gonadotropin-releasing hormone (GnRH) agonists, their results from 75 transgender adults suggested this adverse effect was only temporary for those who continued to receive testosterone therapy.